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These authors described 2 types of endplate and marrow changes:. Surgery for degenerative lumbar disc disease: In a population-based sample of four hundred twelve year old Danes, Kjaer et al 17 observed Modic changes in the lumbar spines of 9.

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Modic changes following lumbar disc herniation.

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In a study of 56 patients treated with anterior lumbar interbody fusion for LBP, Chataigner et al 35 found that patients with type 1 Modic changes had much better outcomes than those with isolated DDD and those with type 2 changes, in whom the results were generally poor. The relationship between Modic type 1 changes and segmental instability is mostly supported by indirect evidence coming from outcome studies following lumbar fusion. These authors proposed that the production of proinflammatory mediators within the nucleus pulposus may be a major factor in the genesis of diskogenic LBP.

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Answer Questions Can I take my meds without food right now? Modic Changes and LBP Kjaer et al 17 suggested that Modic changes constitute the crucial element in the degenerative process around the disk in relation to LBP and clinical findings. Increased signal intensity on T1-weighted images and isointense to marrow or mildly increased signal intensity on T2-weighted images.

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